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It may be South Beach's shy sister--and our healer...
Have started reading up on this. I find it interesting that a lot of the foods pushed on this "diet" are the same ones I have instinctively headed toward during my own health troubles. Now that the holiday food madness has passed, time to get back on South Beach (I never left it totally, just was inclined to sample a few sweets). I may be able to incorporate some of this into my own diet.
This also may explain how some people plateau and can't get lower.
"How, exactly, does chronic inflammation cause leptin resistance? The question and the answer lie at the very heart of the Fat Resistance Diet™.
"Fat biology researchers have uncovered what many believe to be the key mechanisms of leptin resistance. Dr. Jeffrey Flier and his colleagues at Harvard Medical School have led these efforts. They have discovered that a group of molecules involved in reducing inflammation also interfere with leptin signaling on the cell surface and inside the cell. These molecules are known as SOCS, which stands for suppressors of cytokine signaling. Two specific SOCS molecules, SOCS-1 and SOCS-3, have been shown in many animal studies, first by Flier’s group and later by other research teams, to jam the signals that leptin is supposed to deliver to brain cells and muscle cells.
"What is the significance of the fact that SOCS molecules are key causes of leptin resistance—the fundamental factor in stubborn overweight? SOCS-1 and SOCS-3 are both part of the body’s response to inflammation. When working properly, our levels of inflammation are kept in balance by overlapping feedback loops. When particular arms of the inflammation system go into gear, provoked, for example, by the presence of a bacterial invader or a sudden injury, another set of chemicals is released to make certain that the chemistry of inflammation doesn’t spiral out-of-control, causing excessive damage to cells and tissues. SOCS molecules represent the message-carriers in one of these negative feedback loops. Their message to inflammatory cells and cytokines is: "Cool down!" SOCS proteins are an essential part of the body’s system of checks and balances. When they work as they should, SOCS molecules succeed in checking excess inflammation. As inflammation subsides, levels of SOCS subside.
"Immunobiologists believe that overweight people with chronic inflammation have chronically high levels of SOCS, released in a continual effort to damp down their body-wide inflammation. Indeed, elevated SOCS proteins have been found in the brain, liver, muscle, and to a lesser extent, the fat tissue of obese animals. High SOCS levels are a sign that the overweight animal is "over-inflamed" and trying to tone the inflammation down. Studies done at Harvard have found SOCS molecules in the hypothalamus, a walnut-sized structure at the base of the brain that regulates mood, thirst, and hunger. The Harvard studies show that SOCS-1 and SOCS-3 jam leptin’s signal at the internal portion of the leptin receptor. Bottom line: SOCS molecules interrupt leptin’s message to suppress hunger, and they are primary causes of leptin resistance in the brain."
A fat resistance diet?
My specialist used to test for leptin, but stopped because there wasn't anything to be done for leptin awry. If this diet can work for people with chronic inflammation, I'll bet she starts testing for this again.
This also may explain how some people plateau and can't get lower.
"How, exactly, does chronic inflammation cause leptin resistance? The question and the answer lie at the very heart of the Fat Resistance Diet™.
"Fat biology researchers have uncovered what many believe to be the key mechanisms of leptin resistance. Dr. Jeffrey Flier and his colleagues at Harvard Medical School have led these efforts. They have discovered that a group of molecules involved in reducing inflammation also interfere with leptin signaling on the cell surface and inside the cell. These molecules are known as SOCS, which stands for suppressors of cytokine signaling. Two specific SOCS molecules, SOCS-1 and SOCS-3, have been shown in many animal studies, first by Flier’s group and later by other research teams, to jam the signals that leptin is supposed to deliver to brain cells and muscle cells.
"What is the significance of the fact that SOCS molecules are key causes of leptin resistance—the fundamental factor in stubborn overweight? SOCS-1 and SOCS-3 are both part of the body’s response to inflammation. When working properly, our levels of inflammation are kept in balance by overlapping feedback loops. When particular arms of the inflammation system go into gear, provoked, for example, by the presence of a bacterial invader or a sudden injury, another set of chemicals is released to make certain that the chemistry of inflammation doesn’t spiral out-of-control, causing excessive damage to cells and tissues. SOCS molecules represent the message-carriers in one of these negative feedback loops. Their message to inflammatory cells and cytokines is: "Cool down!" SOCS proteins are an essential part of the body’s system of checks and balances. When they work as they should, SOCS molecules succeed in checking excess inflammation. As inflammation subsides, levels of SOCS subside.
"Immunobiologists believe that overweight people with chronic inflammation have chronically high levels of SOCS, released in a continual effort to damp down their body-wide inflammation. Indeed, elevated SOCS proteins have been found in the brain, liver, muscle, and to a lesser extent, the fat tissue of obese animals. High SOCS levels are a sign that the overweight animal is "over-inflamed" and trying to tone the inflammation down. Studies done at Harvard have found SOCS molecules in the hypothalamus, a walnut-sized structure at the base of the brain that regulates mood, thirst, and hunger. The Harvard studies show that SOCS-1 and SOCS-3 jam leptin’s signal at the internal portion of the leptin receptor. Bottom line: SOCS molecules interrupt leptin’s message to suppress hunger, and they are primary causes of leptin resistance in the brain."
A fat resistance diet?
My specialist used to test for leptin, but stopped because there wasn't anything to be done for leptin awry. If this diet can work for people with chronic inflammation, I'll bet she starts testing for this again.
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She is still heavy, but not frighteningly so. This might explain her plateauing for several years... .